In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice.

نویسندگان

  • Charles Mutai
  • Geoffrey Rukunga
  • Constatinos Vagias
  • Vassilios Roussis
چکیده

The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.

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عنوان ژورنال:
  • African journal of traditional, complementary, and alternative medicines : AJTCAM

دوره 5 1  شماره 

صفحات  -

تاریخ انتشار 2007